1. It is created by the products secreted by the cortical granules . 2. Mammalian cortical granules have been shown to contain high levels of carbohydrates. 3. Cortical granule exocytosis has been shown to occur directly following a calcium wave.4. Evidence has indicated the presence of the protein, calreticulin, within the cortical granule . 5. Once the egg is fertilized, then the cortical granules exocytose their contents into the extracellular matrix. 6. The oocyte has cortical granules peripherally located under the cortex that contain a proteolytic protein called metalloendoproteases. 7. As demonstrated in unfertilized vertebrate oocytes, cortical granule exocytosis is induced when calcium is artificially increased. 8. "' Hyalin "'is a protein released from the cortical granules of a egg. 9. An assortment of hypotheses exist concerning the biological function of CGFDs and pre-fertilization cortical granule exocytosis. 10. The proteinases present in mammalian cortical granules primarily serve to modify the zona pelucida during the zona reaction.
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